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Ever had this experience? You splurge on premium dietary supplements, take them faithfully for a month or two, and… feel absolutely nothing.
The problem usually isn't that the ingredients don't work—it's that they're poorly absorbed. Most nutrients get intercepted by your gut or metabolized before they even enter your bloodstream.
As a 20-year veteran in nutritional ingredients, Natural Field unveiled a game-changing solution to this "absorption bottleneck" in our 2025 Liposome White Paper: advanced co-loaded liposome technology. Not only does it drastically boost intestinal absorption of nutrients, but its standardized production also turns "high-efficiency absorption" from a lab concept into a consistent reality across every batch.
Why do so many nutrients struggle to get absorbed? The key culprit is P-glycoprotein (P-gp)—a protein in intestinal epithelial cells that acts like a "reverse transporter." It pumps nutrients that have just entered cells back into the gut, directly slashing absorption efficiency.
This is the core pain point of traditional nutritional ingredients: no matter how pure the ingredients are, if they can't get past the "P-gp barrier," only a tiny fraction will ever reach your bloodstream.
Natural Field's co-loaded liposomes bypass or inhibit P-gp through two core mechanisms, maximizing intestinal absorption:
Mechanism 1: Bypass P-gp—Nanoscale Size Lets Nutrients "Sneak" Into Cells
Our co-loaded liposomes have a nanoscale particle size (50–100nm). Unlike traditional microscale liposomes (10–30μm), they directly enter the body via "endocytosis" in intestinal epithelial cells—completely evading P-gp interception. That's why nanoscale liposomes deliver far higher intestinal absorption than their microscale counterparts.
Mechanism 2: Inhibit P-gp—Reduce Nutrient "Reversal Loss"
Additionally, our co-loaded liposomes specifically inhibit P-gp activity. Experimental data shows significantly enhanced inhibition rates against P-gp-related transporters like MDR1 and BCRP, cutting down nutrient "reversal loss" at the source.
Improved absorption ultimately translates to better bioavailability (the amount of active nutrient that enters the bloodstream). We tested the in-vivo bioavailability of four popular nutrients in rats (data source: Natural Field):
Glutathione: Co-loaded liposomes delivered an AUC (a key bioavailability metric) 2.0x higher than regular liposomes and 4.5x higher than free-form nutrients.
Coenzyme Q10: Co-loaded liposomes showed an AUC 1.8x higher than regular liposomes and 2.6x higher than free-form.
NMN: Co-loaded liposomes achieved an AUC 2.8x higher than regular liposomes and 7.7x higher than free-form.
Creatine: Co-loaded liposomes had an AUC 2.1x higher than regular liposomes and 2.8x higher than free-form.
With advanced co-loaded liposomes, a nutrient that once required 4 servings to absorb 1 serving now delivers the same (or better) results with just 1 serving.
As a company committed to "producing nutritional ingredients with pharmaceutical-grade standards," our advanced co-loaded liposomes aren't just effective—they're consistently high-quality:
Stable, Controlled Particle Size: Nanoscale liposomes are strictly controlled to an average size of 50–100nm with uniform distribution. Electron microscopy and particle size analysis confirm regular particle shape and excellent dispersion.
Standardized Production: Backed by Class 10,000 and Class 100,000 clean workshops and international certifications (FSSC 22000, ISO, etc.), every batch maintains consistent particle size and encapsulation efficiency—eliminating "batch-to-batch variability" that undermines efficacy.
Rigorous Quality Control: Strict technical characterization testing ensures product stability. This is the core confidence that lets us supply global brands like Nestlé and LG.
For 20 years, Natural Field has focused on solving the nutrition industry's core conflict: Consumers want supplements that actually work, but ingredients still face "poor absorption" and "inconsistent quality" issues.
Our advanced co-loaded liposomes are the answer—not just a technology, but a solution to ensure nutrients are truly used by the body.
If you're a dietary supplement brand or formulator looking to move beyond "ingredient stacking" and deliver real, noticeable benefits, we invite you to:
Access the full Liposome White Paper
Request samples of our advanced co-loaded liposomes for testing
Customize liposome encapsulation solutions tailored to your needs
Natural Field—producing truly effective nutritional ingredients to pharmaceutical-grade standards.
