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If you’ve ever felt frustrated by stubborn weight gain, fluctuating blood sugar, or low energy—even when eating well and exercising—you’re not alone. These metabolic roadblocks often stem from a hidden enemy we rarely talk about: senescent cells (aging cells) that build up in the body over time.
For decades, the Mayo Clinic has led the charge in researching "senolytics"—compounds that clear these worn-out cells. Their latest game-changing study, published in the prestigious Cell Metabolism, reveals a critical link between aging, obesity, and metabolism—and a natural solution hiding in your fruit bowl: fisetin, a plant-based compound found in strawberries, apples, and onions.
Let’s break down why this discovery is a game-changer for anyone prioritizing metabolic health and anti-aging.
Endothelial cells line the inside of your blood vessels, acting as gatekeepers for nutrient exchange, regulating blood flow, and even supporting fat metabolism. They’re vital for overall health—until they age.
In obesity (especially when driven by a high-fat diet), endothelial cells surrounding fat tissue age prematurely. Instead of naturally "retiring," these senescent cells linger and release a toxic cocktail of pro-inflammatory molecules called SASP (Senescence-Associated Secretory Phenotype). Think of SASP as "biochemical smoke bombs": they disrupt the surrounding tissue, spark chronic inflammation in fat cells, and trigger metabolic chaos—insulin resistance, high blood sugar, and even faster whole-body aging.
To prove this, the Mayo team designed two groundbreaking experiments:
· Positive Test: When they specifically removed senescent endothelial cells from obese mice, the animals lost fat, improved glucose tolerance, and became more active—their metabolism bounced back!
· Negative Test: Transplanting senescent human endothelial cells into healthy mice caused insulin resistance, increased fat inflammation, and reduced exercise capacity in just weeks. Critically, this didn’t happen in immune-deficient mice—proving SASP-driven immune activation is the root cause.
The takeaway? Senescent endothelial cells are the missing link between obesity and metabolic dysfunction. Clear them, and you unlock healthier metabolism.
Here’s the exciting part: The Mayo team identified fisetin as a powerful, natural senolytic that targets and eliminates senescent endothelial cells—without harming healthy cells.
Fisetin’s superpowers don’t stop there:
· In lab tests, fisetin drastically reduced senescent cell counts (marked by p16 and SA-β-gal markers) in human fat cells and cut SASP levels.
· In mice, intermittent fisetin supplementation (50 mg/kg, 3 days every two weeks) cleared aging cells, restored glucose tolerance, and suppressed aging genes like p16 and p21.
· Unlike anti-inflammatory drugs that only mask symptoms, fisetin attacks the source—removing the "inflammation engines" (senescent cells) for long-lasting metabolic benefits.
It’s nature’s own solution to a modern problem—with science to back it up.
Fisetin is abundant in strawberries (especially ripe ones!), apples, onions, and grapes—but there’s a catch: To reach the effective dose used in the Mayo study, you’d need to eat dozens of kilograms of strawberries every day. That’s impossible for most people.
The solution? High-quality, high-purity fisetin supplements—and partnering with a supplier you can trust to deliver the potency and safety your customers demand.
At Natural Field, we turn scientific breakthroughs into accessible, reliable nutritional ingredients. Since 2005, we’ve been a global leader in developing pharmaceutical-grade supplement ingredients, trusted by brands like Nestlé, LG, and Jingjiu—with products sold in 86 countries.
Our fisetin raw material is designed for maximum impact:
· High Purity & Bioavailability: Leveraging advanced technologies like co-loaded liposome delivery systems (a core strength with 39+ national patents) to ensure fisetin is easily absorbed by the body.
· Customized Support: Whether you’re launching a fisetin supplement, formulating a metabolic health product, or need tailored solutions, our team of 32 R&D experts delivers one-stop service to bring your vision to life.
We don’t just supply ingredients—we empower you to lead the next wave of metabolic health and anti-aging innovation.
The Mayo Clinic’s research proves fisetin isn’t just a "superfood compound"—it’s a science-backed tool to address the root of obesity-related metabolic issues. As consumers increasingly seek natural, evidence-based solutions, fisetin is poised to become a staple in the health and wellness industry.
Partner with Natural Field, and you’ll get:
· Premium, lab-validated fisetin raw material.
· The expertise of a team dedicated to nutritional innovation.
· A trusted global partner with a track record of reliability and quality.
Don’t miss out on this opportunity to turn a groundbreaking discovery into products that transform lives. Contact us today to learn more about our fisetin solutions—and let’s unlock the future of metabolic health together!
Science meets nature—only with Natural Field.
References:
[1] Suda M, Chaib S, Langhi Prata L G P, et al. Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice [J]. Cell metabolism, 2025, 37(12): 2455-65.e6.
[2] Conley S M, Hickson L J, Kellogg T A, et al. Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells [J]. Frontiers in cell and developmental biology, 2020, 8: 197.
