Physiological Functions and Supplementation Needs of Coenzyme Q10

13 Jan 2025
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Coenzyme Q10 is a fat-soluble quinone compound composed of a quinone ring core and a polyisoprene side chain. It is also known as ubiquinone as it is widely present in animals, plants, and microorganisms. The molecular structure of Coenzyme Q10 is similar to that of Vitamin K. It is the only coenzyme Q substance in the human body, an essential compound, and is also referred to as Vitamin Q.


Discovery and Development of Coenzyme Q10


Coenzyme Q10 was first isolated from bovine heart in 1957 by Dr. Frederick Crane's research team in the United States. In 1958, Dr. Karl Folkers of the University of Texas identified the chemical structure of Coenzyme Q10, carried out chemical synthesis, and for the first time, produced Coenzyme Q10 using microbial fermentation in the laboratory.


In 1974, Japan's Nisshin Seifun Group Inc. achieved industrial production of Coenzyme Q10 using a semi-synthetic method and marketed it as a treatment for heart disease in Japan, thus accelerating its application in the medical and health fields. In 1982, China approved Coenzyme Q10 as a prescription drug for the clinical treatment of cardiovascular diseases.


Physiological Functions of Coenzyme Q10


Coenzyme Q10 is a mitochondrial coenzyme crucial for the production of adenosine triphosphate (ATP). In the human body, Coenzyme Q10 can interchange between ubiquinone (oxidized form) and ubiquinol (reduced form), reduce unsaturated fatty acids, maintain the reduced state within cell membranes, and function as an antioxidant. This includes scavenging free radicals, reducing oxidative stress, improving mitochondrial dysfunction, reducing cell apoptosis, protecting the structure and function integrity of cell membranes, reducing skin wrinkles, delaying skin aging, and blocking skin damage, among other CoQ10 benefits.


Additionally, Coenzyme Q10 enhances immunity, regulates blood lipids, strengthens heart function, and boosts cognitive ability. As a metabolic activator, Coenzyme Q10 can activate cellular respiration, providing sufficient oxygen and energy to myocardial and brain cells, thereby maintaining a healthy state for the cells.


Body's Demand for Coenzyme Q10


Coenzyme Q10 is synthesized by the human body, mainly in the liver. However, as age increases and with the occurrence of certain chronic diseases, the body's synthesis ability gradually declines.


  • Normal Demand: Coenzyme Q10 levels in a healthy human body can be maintained through self-synthesis and dietary intake.

  • Additional Demand: The body may require higher levels of Coenzyme Q10 under the following circumstances:

  • Age Increase: Coenzyme Q10 levels start to decline after the age of 30, increasing the demand for Coenzyme Q10 in the elderly.

  • Chronic Diseases: Patients with heart disease, diabetes, Parkinson's disease, and polycystic ovary syndrome may need additional supplementation.

  • Medication Impact: Statin drugs can inhibit the biosynthesis of Coenzyme Q10, leading to reduced levels in the body.


Moreover, dietary intake of Coenzyme Q10 is relatively low and cannot meet higher demand levels. For example:


To achieve the minimum daily supplement dose (30 mg/day), it would be necessary to consume 300 grams of beef heart or 3 kilograms of salmon daily, which is impractical in daily life.


Therefore, for those with additional needs, dietary supplements are usually a more practical, convenient, and efficient method.


As a professional CoQ10 manufacturer, Natural Field provides high-quality Coenzyme Q10 bulk to help enhance the competitiveness of your products. Coenzyme Q10 is an essential nutrient for the human body, and with increasing age and certain health conditions, the body's synthesis ability gradually declines, making additional supplementation particularly important. Our Coenzyme Q10 powder is highly pure and stable, suitable for use in health foods, nutritional supplements, and cosmetics. Choose Natural Field to obtain reliable supplies and meet the market demand for efficient, natural Coenzyme Q10. Welcome to consult for cooperation!

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