Fisetin Powder: A New Force in the Anti-Aging Market

18 Feb 2025
27

Rapid Growth of the Global Anti-Aging Market


According to data, the global anti-aging market size in 2021 had a year-over-year growth rate as high as 11.1%. Additionally, the annual average year-over-year growth rate of the Chinese skincare anti-aging market exceeded 10% between 2017 and 2022. This data indicates that the global anti-aging market is experiencing unprecedented opportunities, particularly in China, which has a vast consumer market. With consumers' increasing pursuit of health and youthful appearance, the demand for anti-aging products has surged, presenting significant market potential.


Among these, orally ingested anti-aging products are considered an important direction for future development. Currently, the ingredients for oral anti-aging products are relatively limited, and there is an urgent need for more efficient food ingredients to drive the industry's growth. This provides ample space and opportunities for the research and application of new anti-aging ingredients.


What is Fisetin?


Among numerous anti-aging ingredients, Fisetin, a flavonoid compound found in plants, has garnered increasing attention in recent years. Fisetin has demonstrated potent anti-aging effects in multiple studies, particularly in the removal of senescent cells, outperforming other plant-based compounds like Quercetin.


Source and Characteristics of Fisetin


Fisetin is a natural plant polyphenol widely found in many plants, including Acacia and Lacquer trees. It was first isolated from plants in 1833 and its chemical structure was further studied and confirmed over the following decades. Fisetin is commonly found in strawberries, apples, persimmons, grapes, onions, and cucumbers, and is a typical natural product.


Because Fisetin is a naturally occurring component, it can be used as an oral dietary supplement without any reported adverse side effects. Therefore, Fisetin not only provides scientific backing for anti-aging but, due to its natural origin and safety, also emerges as a promising candidate in oral anti-aging products.


Mechanisms of Fisetin's Anti-Aging Effects


Fisetin stands out in the anti-aging field due to its unique anti-aging mechanisms. Research has found that Fisetin significantly slows down the aging process by clearing senescent cells and reducing the expression of inflammatory factors. Specifically, Fisetin can selectively clear senescent cells, which typically release harmful inflammatory factors that promote the aging process.


A notably famous paper published in a journal under The Lancet studied the senescent cell-clearing abilities of various plant flavonoids and found Fisetin to be the most potent. The comparison also included Curcumin, Tea Polyphenols, Luteolin, and Myricetin, among others, but Fisetin prevailed. Subsequent animal and ex vivo skin experiments showed promising results for Fisetin. Its mechanism involves reducing the expression of inflammatory factors and clearing senescent cells.


The Future of Oral Anti-Aging: The Vast Application Prospects of Fisetin


As understanding of aging mechanisms deepens, the removal of senescent cells is being recognized as a future trend in the anti-aging field. Fisetin powder, as a Senolytic (a senescent cell-clearing agent), is gradually becoming an important ingredient in anti-aging products. It can not only inhibit the expression of aging-related genes through its anti-inflammatory effects but also promote the health of the skin and other tissues, thus, making oral anti-aging products more marketable. With the rapid growth of the global anti-aging market and the increasing demand for efficient and safe products, the application of Fisetin will become a significant driving force in the development of the oral anti-aging industry.

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