How Does Fisetin Fight Aging?

15 Feb 2025
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Through studies on animals and some clinical trials, scientists have proposed several significant mechanisms by which fisetin may extend lifespan. There are mainly five fisetin benefits: (1) Fisetin can kill senescent cells; (2) Fisetin can improve cognitive decline; (3) Fisetin can prevent the appearance of wrinkles and erythema by inhibiting UVB-induced expression; (4) Fisetin can inhibit cancer cells and prevent the progression of cancer; (5) Fisetin is a plant component beneficial to osteoporosis.


Fisetin Benefits: Elimination of Senescent Cells


Senescent cells secrete harmful substances that may damage other healthy cells nearby.

Another negative impact of senescent cells in the body is that they can also damage stem cells. Stem cells are the foundational cells of the human body, primarily responsible for constructing and healing organs and tissues. Due to damage to stem cells, the body is more prone to fatal diseases, especially cancer.


The ability of fisetin to eliminate senescent cells has shown significant effects in mouse experiments. Compared to mice that did not take fisetin, those that ingested fisetin over a period of time had an increase in average lifespan by about 2.5 months, which is nearly a 10% extension.


Fisetin Benefits: Improvement of Cognitive Decline


Another interesting aspect of fisetin is its ability to reduce cognitive aging in mice. A study found that after administering fisetin, older mice improved their ability to walk through mazes and recognize objects. This indicates that the cognitive and memory abilities of older mice improved. Moreover, older mice became almost as good as younger mice in object recognition and maze navigation.


According to related studies, fisetin has the potential to extend both the median and maximum lifespan of mice, even if they start taking it in later life (equivalent to humans in their 50s or 60s).


Furthermore, in animal models of early-onset Alzheimer's disease, fisetin is believed to have the ability to prevent the development of cognitive and memory impairments.


Fisetin Benefits: Inhibition of UVB-induced Expression


Additionally, fisetin can help reduce the formation of skin wrinkles and enhance the skin layers. This can be achieved by reducing the number of matrix metalloproteinases (MMPs), which degrade the extracellular matrix around cells. The so-called extracellular matrix includes collagen, elastin, hyaluronic acid, glycosaminoglycans (GAGs), and many other molecules that bind with cells. Thus, they can tighten tissues such as the skin and organs. Excessive matrix metalloproteinases can lead to wrinkle formation.


Fisetin Benefits: Inhibition of Cancer Cells


According to reports, fisetin benefits include preventing cancer and restricting the growth and spread of existing tumors. It can induce apoptosis or programmed cell death in cancer cells, aiding in the clearance of tumor cells. Additionally, since fisetin is also an anti-inflammatory agent, it can reduce compounds that exacerbate chronic inflammation and cancer progression.


Fisetin Benefits: Plant Component Beneficial to Osteoporosis


Fragile bones are also a sign of aging, and fisetin is a plant component beneficial in combating osteoporosis. Osteoblasts refer to bone-forming cells, while osteoclasts break down bone cells. These two types of cells depend on each other to function properly and are involved in the process of bone health. When suffering from osteoporosis, osteoclasts are more active than osteoblasts. Studies conducted on rats have shown that fisetin can stimulate the activity of osteoblasts while blocking the activity of osteoclasts.

There is more research on fisetin that is worth noting. So far, fisetin has shown excellent effects in extending lifespan by improving health and reversing aging.
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